STAT3 Luciferase Reporter-HEK293 Cell Line
Product Code
RC1014
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The STAT3 Luciferase Reporter cell line is a stably transfected HEK 293 cell line which expresses Renilla luciferase reporter under the transcriptional control of the STAT3 responsive promoter, so that the cell line is designed to measure the transcriptional activity of STAT3. As a transcription factor, Signal Transducer and Activator of Transcription 3 (STAT3) is activated through phosphorylation at tyrosine 705 in response to various cytokines including IL-6, interferons, epidermal growth factor, hepatocyte growth factor and leukemia inhibitory factor. The phosphorylated STAT3 forms homodimers or heterodimers with STAT1, and the dimers translocate to nucleus in which DNA binding/promoter induction occurs. The STAT3 induction by IL-6 is shown in Figure 1.ÂÂ
| SKU | RC1014 |
|---|---|
| Size | 1 Vial, Each vial contains 2 ~ 3 x 10^6 cells in 1 ml of 90% FBS + 10% DMSO. |
| Application | Application:Monitor the STAT3 signaling pathway activity.Screen for activators or inhibitors of the STAT3 signaling pathway.ÂÂCulture conditions:Cells should be grown at 37°C with 5% CO2 using DMEM medium supplemented with 10% FBS and 1 |
| Storage | Immediately upon receipt, store in liquid nitrogen. |
| Gene id | STAT3 |
| Shipping Temp | Ambient |
| Supplier Name | Boster Biological Technology Ltd |