STAT1 Luciferase Reporter-RAW264.7 Cell Line
Product Code
RC1013
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The STAT1 Luciferase Reporter cell line is a stably transfected RAW264.7 cell line which expresses Renilla luciferase reporter gene under the transcriptional control of the interferon (IFN) gamma activation sequence-based STAT1 response element, so that the cell line is designed to measure the transcriptional activity of STAT1. As a transcription factor, Signal Transducer and Activator of Transcription 1 (STAT1) is activated through phosphorylation at tyrosine 701 in response to various cytokines and growth factors such as IFN-alpha, IFN-gamma, IL-6, EGF and PDGF. The phosphorylated STAT1 forms homodimers or heterodimers with STAT3, and the dimers translocate to nucleus in which DNA binding/promoter induction occurs. The STAT1 induction by IFN-gamma is shown in Figure 1.ÂÂ
| SKU | RC1013 |
|---|---|
| Size | 1 Vial, Each vial contains 2 ~ 3 x 10^6 cells in 1 ml of 90% FBS + 10% DMSO. |
| Application | Application: Monitor the STAT1 signaling pathway activity. Screen for activators or inhibitors of the STAT1 signaling pathway.ÂÂCulture conditions:Cells should be grown at 37°C with 5% CO2 using DMEM medium supplemented with 10% FBS |
| Storage | Immediately upon receipt, store in liquid nitrogen. |
| Gene id | STAT1 |
| Shipping Temp | Ambient |
| Supplier Name | Boster Biological Technology Ltd |