Protein Phosphatases

Protein tyrosine phosphatases (PTPs) are involved in a variety of cellular processes such as signal transduction, cell cycle regulation, and differentiation. The transmembrane Receptor Protein Tyrosine Phosphatases (RPTPs) are key regulators of cell-cell adhesion, immune signaling, and neuronal morphogenesis throughout vertebrate and invertebrate systems. Regulators of RPTPs have been proposed as potential therapeutics for diabetes, obesity, CNS disorders, COPD, and cardiovascular disorders.