IL-15 Responsive Luciferase Reporter Cell Line

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AMS.78402
$11,875.00
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This recombinant Jurkat cell line is a biologically relevant system to measure activation of the IL-15 cytokine receptor by IL-15. The cells were engineered for constitutive expression of human CD122 (IL-15R?; IL-2R?; NM_000878.4), and conditional expression of firefly luciferase driven by STAT5 response elements located upstream of the minimal TATA promoter. Expression of CD122 allows formation of a functional IL-15 receptor at the surface of Jurkat cells, which naturally express high levels of CD132 (also known as IL-15 receptor subunit ?c). Activation of the STAT5 signaling pathway in response to IL-15 or IL-15 analogs can be monitored by measuring luciferase activity.
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SKU AMS.78402
Size 2 vials
Application Characterize recombinant IL-15, IL-15 analogs or other agonists of IL-15RScreen Janus kinase or IL15R inhibitors in a cell-based assay
Storage Cells are shipped in dry ice and should immediately be thawed or stored in liquid nitrogen upon receipt.
Shipping Temp -80C
Supplier Name BPS