Human Fc gamma RIIIA / CD16a (F176) Protein, His Tag (SPR& BLI verified)

Product Code
AMS.CDA-H5220-50ug
$275.00
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CD16 is a low affinity Fc receptor, and has been identified as Fc receptors FcgammaRIIIa (CD16a) and FcgammaRIIIb (CD16b). These receptors bind to the Fc portion of IgG antibodies. CD16 encoded by two different highly homologous genes in a cell type-specific manner.CD16 is found on the surface of natural killer cells, neutrophil polymorphonuclear leukocytes, monocytes and macrophages.; CD16a antigen is also known as Low affinity immunoglobulin gamma Fc region receptor III-A, Fc-gamma RIII-alpha. CD16b is a low-affinity, GPI-linked receptor expressed by neutrophils and eosinophils, whereas CD16a is an intermediate affinity polypeptide-anchored transmembrane glycoprotein expressed natural killer cells, macrophages, subpopulation of T-cells, immature thymocytes and placentaltrophoblasts.CD16a is involved in phagocytosis, secretion of enzymes and inflammatory mediators, antibodydependent cytotoxicity and clearance of immune complexes. Aberrant expression or mutations of CD16a is implicated in susceptibility to recurrent viral infections, systemic lupus erythematosus, and alloimmune neonatal neutropenia.
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SKU AMS.CDA-H5220-50ug
Size 50 ug
Species Human
Expression Host HEK293
Gene symbol Fc gamma RIIIA / CD16a
Tag His
Accession No NP_000560.5
Gene synonyms FCGR3A,CD16A,FCG3,FCGR3,IGFR3
Format Powder
Storage -20C
Shipping Temp Powder,RT