Human CD206 / MMR Protein, His Tag
Product Code
AMS.CD6-H52H9-100ug
Order Support
- Email: [email protected]
Order Support
- Email: [email protected]
Order Support
-
T: +1 (800) 987 0985 (toll free)
-
Email: [email protected]
Order Support
-
Email: [email protected]
Shipping Information
-
Delivery charges will be calculated during checkout
Product Updates
-
Keep up to date with product offers, resources and news
Mrc1 is a conserved checkpoint mediator protein that transduces the replication stress signal to the downstream effector kinase. Mrc1 and its vertebrate homologue Claspin serve as a mediator for replication stress checkpoint signaling, receiving the signal from Mec1/Rad3/ATR sensor kinase and transmitting it to the effector Rad53/Cds1/Chk1 kinase. The loss of mrc1 checkpoint activity results in the aberrant activation of late/dormant origins in the presence of hydroxyurea. Tumor-associated macrophages (TAMs) expressing the multi-ligand endocytic receptor mannose receptor (CD206/MRC1) contribute to tumor immunosuppression, angiogenesis, metastasis, and relapse.
| SKU | AMS.CD6-H52H9-100ug |
|---|---|
| Size | 100 ug |
| Species | Human |
| Expression Host | HEK293 |
| Gene symbol | CD206 |
| Tag | His |
| Accession No | NP_002429.1 |
| Gene synonyms | MMR,CD206,hMR,MRC1,CLEC13D,CLEC13DL,MRC1L1 |
| Format | Powder |
| Storage | -20C |
| Shipping Temp | Powder,RT |