Human CD206 / MMR Protein, His Tag

Product Code
AMS.CD6-H52H9-100ug
$440.00
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Mrc1 is a conserved checkpoint mediator protein that transduces the replication stress signal to the downstream effector kinase. Mrc1 and its vertebrate homologue Claspin serve as a mediator for replication stress checkpoint signaling, receiving the signal from Mec1/Rad3/ATR sensor kinase and transmitting it to the effector Rad53/Cds1/Chk1 kinase. The loss of mrc1 checkpoint activity results in the aberrant activation of late/dormant origins in the presence of hydroxyurea. Tumor-associated macrophages (TAMs) expressing the multi-ligand endocytic receptor mannose receptor (CD206/MRC1) contribute to tumor immunosuppression, angiogenesis, metastasis, and relapse.
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SKU AMS.CD6-H52H9-100ug
Size 100 ug
Species Human
Expression Host HEK293
Gene symbol CD206
Tag His
Accession No NP_002429.1
Gene synonyms MMR,CD206,hMR,MRC1,CLEC13D,CLEC13DL,MRC1L1
Format Powder
Storage -20C
Shipping Temp Powder,RT