GR-GAL4 Reporter (Luc)-HEK293 Cell Line (Glucocorticoid Receptor Pathway)

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AMS.60655
$2,655.00
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The Glucocorticoid Receptor Pathway GAL4 Reporter (Luc) - HEK293 Cell Line contains afirefly luciferase gene under the control of glucocorticoid receptor ligand binding domain that isfused to the DNA binding domain (DBD) of GAL4 (GAL4 DBD-GR) stably integrated intoHEK293 cells. This fusion construct activates firefly luciferase expression under the control of amultimerized GAL4 upstream activation sequence (UAS). This allows for specific detection ofglucocorticoid-induced activation of the glucocorticoid receptor without the need for individualtranscriptional targets and with low cross-reactivity for other nuclear receptor pathways. This cellline is validated for response to stimulation of dexamethasone and to the treatment withmifepristone, an inhibitor of the glucocorticoid signaling pathway.
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SKU AMS.60655
Size 2 vials
Application Monitor glucocorticoid signaling pathway activity and screen activators or inhibitors of the glucocorticoid signaling pathway.
Storage Immediately upon receipt, store in liquid nitrogen.
Species Human
Cell Line HEK293
Tissue Type Kidney
Gene synonyms GAL4, Glucocorticoid Receptor
Shipping Temp -80C
Supplier Name BPS