GAS Reporter (Luc) - HeLa Cell Line (IFN?/JAK/STAT1 Pathway)

Name: GAS Reporter (Luc) - HeLa Cell Line (IFN?/JAK/STAT1 Pathway)
Brand: 79041
SKU: 79041
Price: 2115 USD
Availability: InStock

Product Code

79041

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Overview

The GAS reporter (Luc)-HeLa cell line is designed to monitor the activity of interferon gamma-induced signal transduction pathways in cultured cells by measuring activated STAT1 homodimers. It contains a firefly luciferase gene driven by three copies of the interferon gamma-activated sites (GAS) located upstream of the minimal TATA promoter. IFNgamma first binds to a heterodimeric receptor consisting of two chains, IFNGR1 and IFNGR2, causing its dimerization and the activation of specific Janus family kinases (JAK1 and JAK2). Two STAT1 molecules associate with this ligand-activated receptor complex and are activated by phosphorylation to form active homodimer. The active STAT1 homodimers translocate to the nucleus where they bind interferon gamma-activated sites (GAS) in the promoter of IFNgamma inducible genes, including luciferase reporter gene.

Product Specifications

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SKU	79041
Size	2 vials
Application	Monitor interferon gamma-induced signal transduction pathways. Screen for activators or inhibitors of JAK/STAT1 signaling pathway using the GAS Reporter Cell Line.
Storage	Immediately upon receipt, store in liquid nitrogen.
Species	Human
Cell Line	HELA
Tissue Type	Uterus, Cervix
Gene synonyms	Gas Cell line, GAS reporter cell line, GAS Hela cell line, STAT1, Just another kinase, JAK, INFgamma, Signal transducer and activator of transcription 1, Interferon gamma cell line, JAK pathway bioassay
Shipping Temp	-80C
Supplier Name	BPS

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We are a global provider of human and animal biospecimens: including frozen & FFPE tissue, DNA, RNA, total proteins, blood products and primary cells.

We are a global provider of human and animal biospecimens: including frozen & FFPE tissue, DNA, RNA, total proteins, blood products and primary cells.

We are a global provider of human and animal biospecimens: including frozen & FFPE tissue, DNA, RNA, total proteins, blood products and primary cells.

We are a global provider of human and animal biospecimens: including frozen & FFPE tissue, DNA, RNA, total proteins, blood products and primary cells.

We are a global provider of human and animal biospecimens: including frozen & FFPE tissue, DNA, RNA, total proteins, blood products and primary cells.

We are a global provider of human and animal biospecimens: including frozen & FFPE tissue, DNA, RNA, total proteins, blood products and primary cells.

We are a global provider of human and animal biospecimens: including frozen & FFPE tissue, DNA, RNA, total proteins, blood products and primary cells.

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The CELLBANKER® series of cryopreservation media allows for the stable long-term storage of any cell type, including sensitive cell lines.

The CELLBANKER® series of cryopreservation media allows for the stable long-term storage of any cell type, including sensitive cell lines.

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The CELLBANKER® series of cryopreservation media allows for the stable long-term storage of any cell type, including sensitive cell lines.

The CELLBANKER® series of cryopreservation media allows for the stable long-term storage of any cell type, including sensitive cell lines.

The CELLBANKER® series of cryopreservation media allows for the stable long-term storage of any cell type, including sensitive cell lines.

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AMSBIO offers one of the largest selection of active recombinant enzymes and enzyme activity assays for profiling, inhibitor screening assays, and drug discovery.

AMSBIO offers one of the largest selection of active recombinant enzymes and enzyme activity assays for profiling, inhibitor screening assays, and drug discovery.

AMSBIO offers one of the largest selection of active recombinant enzymes and enzyme activity assays for profiling, inhibitor screening assays, and drug discovery.

AMSBIO offers one of the largest selection of active recombinant enzymes and enzyme activity assays for profiling, inhibitor screening assays, and drug discovery.

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We supply a range of superior magnetic products each uniquely suited to specific protein purification, proteomics and genomics applications.

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GAS Reporter (Luc) - HeLa Cell Line (IFN?/JAK/STAT1 Pathway)

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