Bromodomains
Large portfolio of bromodomain-containing proteins
Bromodomains (BRDs) are protein domains that recognize and bind to acetylated lysine residues on nucleosomes. By transducing the signals conveyed by these residues, bromodomains found on chromatin-associated proteins are able to regulate gene expression by translating these signals into normal or abnormal phenotypes. Bromodomains play a key role in chromatin remodeling and are therefore crucial for epigenetic gene regulation.
Proteins containing bromodomains have been implicated in the development of a large number of diseases including cancer, obesity, inflammation and diabetes.
Our Products
AMSBIO provides an ever-growing portfolio of bromodomains and kits suitable for bromodomain profiling, inhibitor screening assays, and drug discovery.
The Inhibitor Screening Assay Kits are designed to measure the inhibition of bromodomain protein binding to its substrate. The key to the Assay Kits is the highly specific binding of the bromodomains to the acetylated histone substrate.
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The TR-FRET Assay Kits are designed to measure the inhibition of protein binding to its substrate in a homogeneous 384-well reaction format. This FRET-based assay requires no time-consuming washing steps, making it especially suitable for high throughput screening applications. The assay procedure is straightforward and simple.
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