Biotinylated Human IL-2 R gamma / CD132 Protein, His,Avitagâ„¢ (SPR verified)

IL-2R is a heterotrimeric protein binds and responds to the cytokine IL-2. Three distinct chains of IL-2R, termed as alpha, beta and gamma, which are non-covalently associated are identified. The alpha and beta chains are involved in binding IL-2, while signal transduction following cytokine interaction is carried out by the gamma chain, along with the beta subunit. The alpha chain of the IL-2R can bind to the beta chain before receptor interaction with IL-2. The gamma chain alone has a very weak affinity for IL-2, but after the ligand is bound to the alpha/beta heterodimer, the gamma chain becomes recruited to the complex to form a very stable macromolecular quaternary ligand/receptor complex. ; Interleukin-2 receptor subunit gamma (IL2RG), also known as cytokine receptor common subunit gamma, CD antigen CD132, gammaC, p64, which belongs to the type I cytokine receptor family or type 5 subfamily. IL2RG is located on the surface of immature blood-forming cells in bone marrow. Defects in IL2RG are the cause of severe combined immunodeficiency X-linked T-cell-negative/B-cell-positive/NK-cell-negative (XSCID).

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