Anti-BCMA CAR-T Cells
Product Code
AMS.78660-1
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The anti-BCMA CAR-T cells are produced by high-titer lentiviral transduction of human primary CD4+CD8+ T cells using the anti-BCMA CAR Lentivirus ( Bioscience #78655). These ready-to-use CAR-T cells express an anti-BCMA CAR consisting of the ScFv of BCMA (clone C11D5.3) linked to a 2nd generation CAR (Chimeric Antigen Receptor) containing CD8 hinge and transmembrane domains, and the 4-1BB and CD3ζ signaling domains (Figure 1). These CAR-T cells have been validated using flow cytometry (to determine the CAR expression) and co-culture cytotoxicity assays.
Figure 1: Construct diagram showing components of the anti-BCMA CAR expressed in anti-BCMA CAR-T cells.
| SKU | AMS.78660-1 |
|---|---|
| Size | 1 vial |
| Application | Positive control for anti-BCMA CAR-T cellsScreen inhibitors or activators of anti-BCMA CAR-T cytotoxicityDesign and optimize co-culture cytotoxicity assay |
| Storage | Cells are shipped in dry ice and should immediately be thawed or stored in liquid nitrogen upon receipt. Do not use a -80C freezer for long term storage. |
| Shipping Temp | -80C |
| Supplier Name | BPS |