Anti-BCMA CAR Lentivirus (Clone C11D5.3 ScFv-CD8-4-1BB-CD3?)
Product Code
AMS.78655
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The anti-BCMA CAR lentiviruses are replication incompetent, HIV-based, VSV-G-pseudotyped lentiviral particles that are ready to infect almost all types of mammalian cells, including primary and non-dividing cells. These viruses transduce the ScFv (single-chain variable fragment) of anti-BCMA (clone C11D5.3) linked to a 2nd generation CAR (Chimeric Antigen Receptor) containing CD8 hinge and transmembrane domains, and the 4-1BB and CD3ζ signaling domains (Figure 1). The lentiviruses also transduce a puromycin selection gene.
Figure 1. (A) Schematic of the lenti-vector used to generate the anti-BCMA CAR lentivirus with puromycin selection, and (B) Construct diagram showing components of the anti-BCMA CAR
| SKU | AMS.78655 |
|---|---|
| Size | 50 ul |
| Application | Positive control for anti-BCMA CAR evaluation in T cellsTransduction optimization studies |
| Storage | Lentiviruses are shipped with dry ice. For long term storage, it is recommended to store the virus at -80C. |
| Shipping Temp | -80C |
| Supplier Name | BPS |